Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309451 | 0.98 | LMNA (0.38) | LMNATRPA1TSHRTP53SIGMAR1 | |
| Tetramethylammonium Ion SCHEMBL1412797 | 0.93 | LMNA (0.35) | LMNATRPA1TSHRTP53SIGMAR1 | |
| Tetrahexylammonium SCHEMBL12004399 | 0.82 | DNM1 (0.44) | LMNATSHRTP53SLC6A2SLC6A4 | |
| SCHEMBL8757654 | 0.76 | MAPT (0.38) | LMNATRPA1TSHRMEN1KMT2A | |
| SCHEMBL8757321 | 0.76 | SLC6A3 (0.38) | LMNATSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9003677 | 0.75 | CYP2A6 (0.41) | LMNATSHRMAOACYP2A6KCNH2 | |
| SCHEMBL9003380 | 0.72 | CA12 (0.44) | TSHRSLC6A4MAOA | |
| SCHEMBL8756322 | 0.72 | ALDH1A1 (0.37) | LMNATRPA1TSHRSIGMAR1TAAR1 | |
| SCHEMBL8390866 | 0.71 | TAAR1 (0.39) | LMNATRPA1TSHRTP53SIGMAR1 | |
| SCHEMBL4829324 | 0.70 | LMNA (0.38) | LMNATRPA1TSHRTP53SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500453-A | INITIATOR FOR PHOTOSENSITIVE FREE RADICAL CURING/ POLYMERIZATION OF UNSATURATED COMPOUNDS | TOYO INK MANUFACTURING CO., LTD. (JP) | 1996-03-19 | — | — | US | disclosed |