Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14734829 | 0.92 | DNM1 (0.50) | DNM1KDM4EPMP22ATMALDH1A1 | |
| Hydrochloric Acid SCHEMBL27408052 | 0.90 | DNM1 (0.48) | DNM1KDM4EPMP22ATMALDH1A1 | |
| SCHEMBL272419 | 0.89 | DNM1 (0.52) | DNM1KDM4EPMP22ATMALDH1A1 | |
| Iodide SCHEMBL14777716 | 0.87 | DNM1 (0.50) | DNM1KDM4EPMP22ATMALDH1A1 | |
| Water SCHEMBL319990 | 0.87 | DNM1 (0.50) | DNM1KDM4EPMP22ATMALDH1A1 | |
| Bromide SCHEMBL7214859 | 0.87 | DNM1 (0.55) | DNM1KDM4EPMP22ATMALDH1A1 | |
| SCHEMBL11591468 | 0.85 | DNM1 (0.39) | DNM1KDM4EPMP22ATMALDH1A1 | |
| SCHEMBL11706247 | 0.84 | DNM1 (0.46) | DNM1KDM4EPMP22ATMALDH1A1 | |
| Water SCHEMBL3308247 | 0.81 | DNM1 (0.43) | DNM1KDM4EPMP22ATMALDH1A1 | |
| SCHEMBL1686201 | 0.81 | DNM1 (0.57) | DNM1ALDH1A1SLC22A1TSHRSLC22A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0566270-B1 | Coated recording sheets | XEROX CORP (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5212008-A | Coated recording sheets | XEROX CORPORATION (US) | 1993-05-18 | — | — | US | disclosed |