Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HCN1 | O60741 | 2/20 | 0.42 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9004423 | 0.86 | ALDH1A1 (0.63) | MAPTCRHBPCRHR2NPSR1TDP1 | |
| SCHEMBL30568850 | 0.84 | TDP1 (0.68) | MAPTLMNANPSR1TDP1ALDH1A1 | |
| SCHEMBL9004372 | 0.84 | MAPT (0.50) | MAPTCRHBPCRHR2NPSR1ALDH1A1 | |
| SCHEMBL11576468 | 0.80 | MAPT (0.56) | MAPTLMNACRHBPCRHR2NPSR1 | |
| SCHEMBL796040 | 0.79 | MAPT (0.53) | MAPTLMNACRHBPCRHR2NPSR1 | |
| SCHEMBL9004390 | 0.78 | MAPT (0.47) | MAPTCRHBPCRHR2NPSR1TDP1 | |
| SCHEMBL13752166 | 0.77 | MAPT (0.73) | MAPTCRHBPCRHR2NPSR1TDP1 | |
| SCHEMBL8795019 | 0.75 | LMNA (0.48) | MAPTLMNANPSR1TDP1ALDH1A1 | |
| SCHEMBL7511418 | 0.74 | MAPT (0.57) | MAPTCRHBPCRHR2NPSR1TDP1 | |
| SCHEMBL12670293 | 0.74 | PDE4A (0.47) | MAPTLMNANPSR1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574037-A | MODULATED BY SINO-ATRIAL NODE, ANTIISCHEMIC AGENT | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-11-12 | — | — | US | disclosed |
| US-5332737-A | Cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0431856-A2 | Heterocyclic compounds | ZENECA LIMITED (GB) | 1991-06-12 | — | — | EP | disclosed |