SCHEMBL900553

SCHEMBL900553

Cc1c(F)cccc1SC(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.34
PDE2A O00408 1/20 0.34
FFAR4 Q5NUL3 2/20 0.33
HCAR1 Q9BXC0 1/20 0.32
ALOX5AP P20292 1/20 0.32
FEN1 P39748 1/20 0.32
ALDH1A1 P00352 3/20 0.32
HSD11B1 P28845 1/20 0.32
PKM P14618 1/20 0.32
HPGD P15428 1/20 0.32
HTT P42858 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
GNRHR P30968 1/20 0.32
PGR P06401 1/20 0.31
AR P10275 1/20 0.31
GAA P10253 1/20 0.31
CHRM3 P20309 1/20 0.31
KDM4E B2RXH2 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
ESR1 P03372 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16707483 0.81 TRPA1 (0.43) ACHEFFAR4HCAR1ALDH1A1PKM
SCHEMBL576170 0.78 ACHE (0.40) ACHEALDH1A1GAAESR1ESR2
SCHEMBL577112 0.78 ACHE (0.40) ACHEALDH1A1GAAESR1ESR2
SCHEMBL1958637 0.78 ALDH1A1 (0.39) ACHEPDE2AFFAR4HCAR1ALOX5AP
SCHEMBL16707489 0.77 ALDH1A1 (0.37) PDE2AFFAR4HCAR1ALDH1A1PKM
SCHEMBL17384528 0.76 ACHE (0.39) ACHEALDH1A1GAAKDM4EESR1
SCHEMBL900552 0.75 ALOX5AP (0.32) PDE2AALOX5APFEN1ALDH1A1PKM
SCHEMBL900417 0.75 SMN1; SMN2 (0.35) ACHEPDE2AFFAR4HCAR1ALDH1A1
SCHEMBL4564482 0.74 ACHE (0.37) ACHEHCAR1ALDH1A1GAAESR1
SCHEMBL173020 0.71 HSD11B1 (0.45) ACHEALDH1A1HSD11B1L3MBTL1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2621922-A1 A PROCESS FOR THE SYNTHESIS OF THIO-TRIAZOLO-GROUP CONTAINING COMPOUNDS BASF SE (DE) 2013-08-07 EP disclosed
WO-2012041858-A1 A PROCESS FOR THE SYNTHESIS OF THIO-TRIAZOLO-GROUP CONTAINING COMPOUNDS BASF SE (DE) 2012-04-05 WO disclosed