SCHEMBL9006689

SCHEMBL9006689

O=C(/C=C/c1ccc(F)cc1)/C=C/c1ccc(OC(F)=C(F)F)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 2/20 0.66
F3 P13726 2/20 0.51
GSK3B P49841 3/20 0.49
BACE1 P56817 3/20 0.49
TNFRSF1A P19438 1/20 0.47
MAOB P27338 2/20 0.46
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
TYR P14679 1/20 0.44
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
TP53 P04637 1/20 0.44
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9006693 1.00 HSD11B1 (0.66) HSD11B1F3GSK3BBACE1TNFRSF1A
SCHEMBL9006668 0.94 F3 (0.58) HSD11B1F3GSK3BBACE1CYP2D6
SCHEMBL9006591 0.94 F3 (0.58) HSD11B1F3GSK3BBACE1CYP2D6
SCHEMBL9006794 0.89 HSD11B1 (0.53) HSD11B1F3GSK3BBACE1TNFRSF1A
SCHEMBL9006799 0.89 HSD11B1 (0.53) HSD11B1F3GSK3BBACE1TNFRSF1A
SCHEMBL9006742 0.88 F3 (0.62) HSD11B1F3GSK3BBACE1MAOB
SCHEMBL9006616 0.88 F3 (0.59) HSD11B1F3GSK3BBACE1TNFRSF1A
SCHEMBL9006741 0.88 F3 (0.62) HSD11B1F3GSK3BBACE1MAOB
SCHEMBL9006612 0.88 F3 (0.59) HSD11B1F3GSK3BBACE1TNFRSF1A
SCHEMBL9006778 0.87 NFE2L2 (0.55) HSD11B1KMT2ANFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US claimed
EP-0676062-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1995-10-11 EP claimed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US claimed
WO-1994015258-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1994-07-07 WO claimed
US-5489623-A APPLYING POLYMER TO SURFACE, EXPOSING TO INCIDENT PHOTONICRADIATION TO RENDER PORTIONS LESS SOLUBLE OR DISPERSIBLE THE DOW CHEMICAL COMPANY (US) 1996-02-06 US disclosed
EP-0676062-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1995-10-11 EP disclosed
US-5426164-A Solvent and chemical resistant coatings and photoresists; photocuring of perfluorovinyl polymers containing photo active sites; cyclization THE DOW CHEMICAL COMPANY (US) 1995-06-20 US disclosed
WO-1994015258-A1 PHOTODEFINABLE POLYMERS CONTAINING PERFLUOROCYCLOBUTANE GROUPS THE DOW CHEMICAL COMPANY (US) 1994-07-07 WO disclosed