Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.62 |
| ▸ | CCR2 | P41597 | 3/20 | 0.56 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30821752 | 0.84 | KIF18A (0.64) | KIF18ACCR2VCAM1TSHRMAPK1 | |
| SCHEMBL1052777 | 0.84 | KIF18A (0.64) | KIF18ACCR2VCAM1TSHRMAPK1 | |
| SCHEMBL7813933 | 0.82 | KIF18A (0.62) | KIF18ACCR2VCAM1TSHRMAPK1 | |
| SCHEMBL32679728 | 0.82 | KIF18A (0.62) | KIF18ACCR2VCAM1TSHRMAPK1 | |
| SCHEMBL27334707 | 0.82 | KIF18A (0.62) | KIF18AVCAM1TSHRMAPK1MAPT | |
| SCHEMBL14866071 | 0.81 | KIF18A (0.57) | KIF18ACCR2VCAM1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL28104854 | 0.81 | KIF18A (0.60) | KIF18ACCR2VCAM1TSHRMAPK1 | |
| SCHEMBL12377069 | 0.80 | ALDH1A1 (0.56) | VCAM1TSHRMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL4067424 | 0.80 | TSHR (0.60) | CCR2VCAM1TSHRMAPTPOLB | |
| SCHEMBL752794 | 0.79 | KIF18A (0.59) | KIF18ACCR2VCAM1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180487-B2 | Substituted cyanoindoline derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-11-23 | — | — | US | disclosed |
| US-20210087182-A1 | NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-03-25 | — | — | US | disclosed |
| US-20140038822-A1 | USE OF SUBSTITUTED SPIROCYCLIC SULFONAMIDOCARBOXYLIC ACIDS, CARBOXYLIC ESTERS THEREOF, CARBOXAMIDES THEREOF AND CARBONITRILES THEREOF OR SALTS THEREOF FOR ENHANCEMENT OF STRESS TOLERANCE IN PLANTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-06 | — | — | US | disclosed |
| EP-0394943-B1 | Silver halide color photographic material | FUJI PHOTO FILM CO LTD (JP) | 1996-11-20 | — | — | EP | disclosed |
| US-5066577-A | Colorfast cyan dye for diffusion transfer photography process | FUJI PHOTO FILM CO., LTD. (JP) | 1991-11-19 | — | — | US | disclosed |
| EP-0394943-A2 | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1990-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210087182-A1 | NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS | NFKBIA, IKBKG, IKBKB | KIF18A 2653/4885CCR2 564/4885VCAM1 1275/4885 |
| US-11180487-B2 | Substituted cyanoindoline derivatives as NIK inhibitors | NFKBIA, MAP3K14, IKBKG | KIF18A 2559/4885CCR2 380/4885VCAM1 1163/4885 |
| US-20140038822-A1 | USE OF SUBSTITUTED SPIROCYCLIC SULFONAMIDOCARBOXYLIC ACIDS, CARBOXYLIC ESTERS THEREOF, CARBOXAMIDES THEREOF AND CARBONITRILES THEREOF OR SALTS THEREOF FOR ENHANCEMENT OF STRESS TOLERANCE IN PLANTS | STS, SCLY, TST | KIF18A 4783/4885CCR2 1219/4885VCAM1 4827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.