Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902716 | 1.00 | KARS1 (0.46) | KARS1PRKD1NMT1CDK4PDE10A | |
| SCHEMBL901846 | 0.88 | KARS1 (0.46) | KARS1PDE10AADORA2A | |
| SCHEMBL1755670 | 0.84 | KARS1 (0.40) | KARS1 | |
| SCHEMBL901236 | 0.84 | KARS1 (0.40) | KARS1 | |
| SCHEMBL901708 | 0.84 | KARS1 (0.66) | KARS1PRKD1 | |
| SCHEMBL901860 | 0.83 | KARS1 (0.46) | KARS1PRKD1 | |
| SCHEMBL901245 | 0.82 | KARS1 (0.52) | KARS1PRKD1 | |
| SCHEMBL901688 | 0.80 | KARS1 (0.48) | KARS1 | |
| SCHEMBL902032 | 0.80 | KARS1 (0.52) | KARS1PRKD1CDK4CDK6 | |
| SCHEMBL1704237 | 0.79 | WNT1 (0.41) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |