Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 5/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755675 | 1.00 | WNT1 (0.41) | WNT1CLK2CLK3GSK3BDYRK1A | |
| SCHEMBL1755670 | 0.83 | KARS1 (0.40) | KARS1PIM1ROCK2ROCK1 | |
| SCHEMBL901236 | 0.83 | KARS1 (0.40) | KARS1PIM1ROCK2ROCK1 | |
| SCHEMBL901409 | 0.83 | KARS1 (0.41) | WNT1GSK3BDYRK1AKARS1 | |
| SCHEMBL901688 | 0.80 | KARS1 (0.48) | KARS1ROCK2ROCK1 | |
| SCHEMBL901846 | 0.80 | KARS1 (0.46) | KARS1 | |
| SCHEMBL901300 | 0.80 | KARS1 (0.49) | KARS1 | |
| SCHEMBL901301 | 0.79 | KARS1 (0.46) | KARS1 | |
| SCHEMBL902716 | 0.79 | KARS1 (0.46) | KARS1 | |
| SCHEMBL901708 | 0.78 | KARS1 (0.66) | DYRK1AKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |