Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705250 | 0.87 | ACHE (0.47) | LRRK2 | |
| SCHEMBL901702 | 0.87 | KARS1 (0.51) | MAPK1LMNAFAAHKARS1MAPK10 | |
| SCHEMBL901954 | 0.86 | FAAH (0.41) | MAPK1LMNAFAAHKARS1MAPK10 | |
| SCHEMBL901949 | 0.85 | KARS1 (0.48) | KARS1KMT2APARP1 | |
| SCHEMBL902548 | 0.85 | JAK2 (0.41) | KARS1PARP1LRRK2KRAS | |
| SCHEMBL1704872 | 0.85 | KARS1 (0.48) | KARS1MAPK14LRRK2 | |
| SCHEMBL901573 | 0.81 | MAPK1 (0.42) | MAPK1LMNAMAPK10TSHRKDM4E | |
| SCHEMBL901704 | 0.75 | CKS1B (0.48) | KARS1LRRK2 | |
| SCHEMBL901890 | 0.75 | KARS1 (0.45) | MAPK1LMNAFAAHKARS1 | |
| SCHEMBL902751 | 0.74 | CKS1B (0.47) | KARS1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |