Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901912 | 0.85 | CKS1B (0.52) | LRRK2POLBCKS1BSKP1SKP2 | |
| SCHEMBL901705 | 0.85 | P2RX7 (0.38) | MAPK1LMNAKDM4ETSHRRCE1 | |
| SCHEMBL901353 | 0.81 | MAPK1 (0.41) | MAPK1LMNAKDM4ETSHRRCE1 | |
| SCHEMBL901702 | 0.80 | KARS1 (0.51) | MAPK1LMNAMAPK10SLC6A7 | |
| SCHEMBL901949 | 0.80 | KARS1 (0.48) | KMT2APOLBPARP1 | |
| SCHEMBL3442387 | 0.78 | ALDH1A1 (0.56) | MAPK1LMNAKDM4ETSHRGRM5 | |
| SCHEMBL901954 | 0.78 | FAAH (0.41) | MAPK1LMNAKDM4ETSHRRCE1 | |
| SCHEMBL902548 | 0.78 | JAK2 (0.41) | LRRK2PARP1 | |
| SCHEMBL31590360 | 0.75 | SLC6A7 (0.49) | MAPK1KDM4EGRM5SMN1; SMN2HTT | |
| SCHEMBL1704938 | 0.74 | CKS1B (0.40) | MAPK1LRRK2POLBCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |