Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 12/20 | 0.59 |
| ▸ | DRD3 | P35462 | 14/20 | 0.59 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9013599 | 1.00 | DRD3 (0.59) | DRD3DRD2KCNA5 | |
| Fumaric Acid SCHEMBL9013324 | 0.96 | DRD3 (0.62) | DRD3DRD2KCNA5 | |
| Maleic Acid SCHEMBL9013322 | 0.96 | DRD3 (0.62) | DRD3DRD2KCNA5 | |
| Maleic Acid SCHEMBL9013486 | 0.88 | ESR1 (0.48) | DRD2 | |
| Fumaric Acid SCHEMBL9013491 | 0.88 | ESR1 (0.48) | DRD2 | |
| Fumaric Acid SCHEMBL9013669 | 0.85 | HTR1A (0.50) | DRD2 | |
| Maleic Acid SCHEMBL9013664 | 0.85 | HTR1A (0.50) | DRD2 | |
| Hydrochloric Acid SCHEMBL9013338 | 0.80 | ESR1 (0.64) | — | |
| Fumaric Acid SCHEMBL9013612 | 0.79 | KDM4E (0.50) | — | |
| Maleic Acid SCHEMBL9013610 | 0.79 | KDM4E (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589477-A | LEARNING ENHANCEMENT, CNS | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0555478-A1 | PYRIMIDINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1993-08-18 | — | — | EP | disclosed |