Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014383 | 0.80 | MTNR1A (0.40) | MTNR1AMTNR1BMAP3K14L3MBTL1 | |
| SCHEMBL9014723 | 0.76 | MAP3K14 (0.36) | MTNR1AMTNR1BMAP3K14 | |
| SCHEMBL9014396 | 0.75 | MAP3K14 (0.35) | MTNR1AMTNR1BMAP3K14 | |
| SCHEMBL9015271 | 0.75 | MAP3K14 (0.35) | MTNR1AMTNR1BMAP3K14 | |
| SCHEMBL9014644 | 0.74 | KCNH2 (0.59) | — | |
| SCHEMBL9014349 | 0.72 | CHRNB4 (0.36) | ALDH1A1MAP3K14RAB9AL3MBTL1MEN1 | |
| SCHEMBL9014726 | 0.72 | MAP3K14 (0.33) | MTNR1AMTNR1BMAP3K14RAB9AKMT2A | |
| SCHEMBL9014727 | 0.69 | KCNH2 (0.38) | MTNR1AMTNR1BLMNA | |
| SCHEMBL2961606 | 0.67 | MTNR1A (0.57) | MTNR1ACASP1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL10813137 | 0.66 | MTNR1B (0.55) | MTNR1AMTNR1BCASP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |