Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014723 | 0.84 | MAP3K14 (0.36) | MAP3K14MTNR1AMTNR1B | |
| SCHEMBL9015271 | 0.83 | MAP3K14 (0.35) | MAP3K14MTNR1AMTNR1B | |
| SCHEMBL9014787 | 0.80 | HTR1A (0.39) | MAP3K14 | |
| SCHEMBL9014726 | 0.80 | MAP3K14 (0.33) | MAP3K14MTNR1AMTNR1B | |
| SCHEMBL9014349 | 0.78 | CHRNB4 (0.36) | MAP3K14CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL9014727 | 0.76 | KCNH2 (0.38) | MTNR1AMTNR1B | |
| SCHEMBL9014383 | 0.76 | MTNR1A (0.40) | MAP3K14MTNR1AMTNR1B | |
| SCHEMBL9014337 | 0.75 | MTNR1A (0.42) | MAP3K14MTNR1AMTNR1B | |
| SCHEMBL9014335 | 0.71 | KDM4E (0.37) | MTNR1AMTNR1BCHRNB4CHRNA3CHRNB2 | |
| SCHEMBL9772853 | 0.66 | KCNH2 (0.44) | MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |