Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014723 | 0.79 | MAP3K14 (0.36) | MAP3K14 | |
| SCHEMBL9015271 | 0.78 | MAP3K14 (0.35) | SMN1; SMN2MAP3K14 | |
| SCHEMBL9014396 | 0.78 | MAP3K14 (0.35) | CHRNB4CHRNA3CHRNB2CHRNA4MAP3K14 | |
| SCHEMBL9014643 | 0.75 | TERT (0.38) | CHRNB4CHRNA3ALDH1A1ACHEMEN1 | |
| SCHEMBL9014787 | 0.74 | HTR1A (0.39) | MAP3K14 | |
| SCHEMBL9014726 | 0.74 | MAP3K14 (0.33) | KMT2ANPC1TDP1MAP3K14RAB9A | |
| SCHEMBL9014337 | 0.72 | MTNR1A (0.42) | ALDH1A1L3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL9014727 | 0.71 | KCNH2 (0.38) | SMN1; SMN2 | |
| SCHEMBL5839690 | 0.66 | MAPT (0.43) | CHRNB4CHRNA3ALDH1A1HPGDMAPT | |
| SCHEMBL10407545 | 0.64 | HSP90AA1 (0.38) | CHRNB4CHRNA3ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |