Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.32 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | CTSG | P08311 | 1/20 | 0.31 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.31 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014723 | 0.84 | MAP3K14 (0.36) | MAP3K14MTNR1AMTNR1B | |
| SCHEMBL9014396 | 0.83 | MAP3K14 (0.35) | MAP3K14MTNR1AMTNR1B | |
| SCHEMBL9014726 | 0.80 | MAP3K14 (0.33) | MAP3K14MTNR1AMTNR1B | |
| SCHEMBL9014787 | 0.80 | HTR1A (0.39) | MAP3K14CTSGKLK7KLK14KLK5 | |
| SCHEMBL9014349 | 0.78 | CHRNB4 (0.36) | MAP3K14SMN1; SMN2 | |
| SCHEMBL9014727 | 0.76 | KCNH2 (0.38) | SMN1; SMN2MTNR1AMTNR1B | |
| SCHEMBL9014383 | 0.76 | MTNR1A (0.40) | MAP3K14MTNR1AMTNR1B | |
| SCHEMBL9014337 | 0.75 | MTNR1A (0.42) | MAP3K14MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL29960492 | 0.72 | MAP3K14 (0.41) | MAP3K14OPRL1AHR | |
| SCHEMBL9014788 | 0.71 | ADRA2A (0.40) | MAP3K14SMN1; SMN2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |