Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.45 |
| ▸ | PRCP | P42785 | 5/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014749 | 0.92 | DRD2 (0.53) | DRD2PRCPSIGMAR1 | |
| SCHEMBL9014672 | 0.88 | DRD2 (0.55) | DRD2DRD3SIGMAR1KCNH2CHRM4 | |
| SCHEMBL9014708 | 0.84 | KCNH2 (0.61) | DRD2SLC6A4MEN1KMT2AKCNH2 | |
| SCHEMBL9014782 | 0.84 | KCNH2 (0.47) | DRD2DRD3SLC6A4KCNH2 | |
| SCHEMBL9014707 | 0.79 | DRD2 (0.52) | DRD2PRCPDRD4DRD3MEN1 | |
| SCHEMBL9014839 | 0.78 | DRD2 (0.54) | DRD2SIGMAR1KCNH2CHRM4 | |
| SCHEMBL11839176 | 0.75 | DRD2 (0.57) | DRD2PRCPKMT2ASIGMAR1 | |
| SCHEMBL6790341 | 0.75 | DRD2 (0.55) | DRD2MCHR1DRD4DRD3SIGMAR1 | |
| SCHEMBL6792592 | 0.74 | DRD2 (0.52) | DRD2MCHR1DRD4SLC6A4MEN1 | |
| SCHEMBL9014725 | 0.73 | KCNH2 (0.63) | DRD2DRD4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |