Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | PRCP | P42785 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014719 | 0.91 | SIGMAR1 (0.52) | DRD2PRCPMEN1KMT2ASIGMAR1 | |
| SCHEMBL9014362 | 0.82 | KCNH2 (0.65) | DRD2KCNH2 | |
| SCHEMBL9014765 | 0.82 | KCNH2 (0.50) | DRD2SIGMAR1DRD3DRD4KCNH2 | |
| SCHEMBL9014357 | 0.79 | DRD2 (0.54) | DRD2PRCPMEN1KMT2ASIGMAR1 | |
| SCHEMBL9014380 | 0.74 | KCNH2 (0.48) | DRD2MEN1KMT2ASIGMAR1DRD3 | |
| SCHEMBL9967731 | 0.72 | DRD2 (0.68) | DRD2PRCPMEN1KMT2ADRD3 | |
| SCHEMBL9014679 | 0.70 | DRD2 (0.57) | DRD2SIGMAR1KCNH2 | |
| SCHEMBL11839176 | 0.70 | DRD2 (0.57) | DRD2PRCPKMT2ASIGMAR1HTR1A | |
| SCHEMBL6790341 | 0.70 | DRD2 (0.55) | DRD2SIGMAR1DRD3DRD4KCNH2 | |
| SCHEMBL9014749 | 0.69 | DRD2 (0.53) | DRD2PRCPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |