Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.55 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642197 | 0.91 | ALOX5 (0.54) | CYP4F2CYP4A11NPC1LMNAGLA | |
| SCHEMBL1205512 | 0.90 | CYP4F2 (0.52) | CYP4F2CYP4A11NPC1LMNAGLA | |
| SCHEMBL9278298 | 0.89 | PPARA (0.49) | CYP4F2CYP4A11NPC1MAOBPPARG | |
| SCHEMBL4425984 | 0.89 | CYP4F2 (0.64) | CYP4F2CYP4A11TDP1PPARGPPARA | |
| SCHEMBL11066194 | 0.88 | NPC1 (0.46) | CYP4F2CYP4A11NPC1LMNAGLA | |
| SCHEMBL879289 | 0.84 | CYP4F2 (0.58) | CYP4F2CYP4A11TDP1TAAR1PPARG | |
| SCHEMBL2485584 | 0.84 | MAOB (0.58) | NPC1LMNAGLAMAOBMAPT | |
| SCHEMBL901672 | 0.84 | TAAR1 (0.53) | AKR1C3MAOBAKR1C2TAAR1MAPT | |
| SCHEMBL13104077 | 0.84 | CYP4F2 (0.58) | CYP4F2CYP4A11TDP1MAPTPPARG | |
| SCHEMBL7857817 | 0.83 | CYP4F2 (0.57) | CYP4F2CYP4A11TDP1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133915-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2021-07-01 | — | — | WO | disclosed |
| CN-107698528-A | A kind of preparation method of 3-triazole compounds | 湖南华腾制药有限公司 | 2018-02-16 | — | — | CN | disclosed |
| US-20130252951-A1 | 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | PROXIMAGEN LIMITED (GB) | 2013-09-26 | — | — | US | disclosed |
| CN-103328479-A | 7-hydroxy-pyrazolo [1,5-a ] pyrimidine compounds and their use as CCR2 receptor antagonists | PROXIMAGEN LTD | 2013-09-25 | — | — | CN | disclosed |
| EP-2621928-A1 | 7-HYDROXY-PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | Proximagen Limited (GB) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041817-A1 | 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | PROXIMAGEN LTD (GB) | 2012-04-05 | — | — | WO | disclosed |
| CN-1159287-C | Anticonvulsant and sentral nervous system-active bis (fluorophenyl) alkylamides | NPSҩ������˾ | 2004-07-28 | — | — | CN | disclosed |
| CN-1284056-A | Anticonvulsant and sentral nervous system-active bis (fluorophenyl) alkylamides | NPS PHARMA INC (US) | 2001-02-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252951-A1 | 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS | CCR2, CCR5, CCR1 | CYP4F2 1184/4885CYP4A11 639/4885NPC1 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.