Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901298 | 0.94 | KARS1 (0.64) | KARS1SIRT2JAK2JAK1TYK2 | |
| SCHEMBL1755681 | 0.94 | KARS1 (0.56) | KARS1SIRT2JAK2JAK1TYK2 | |
| SCHEMBL902309 | 0.81 | KARS1 (0.49) | KARS1 | |
| SCHEMBL902055 | 0.80 | KARS1 (0.88) | KARS1 | |
| SCHEMBL1755672 | 0.80 | KARS1 (0.49) | KARS1 | |
| SCHEMBL901538 | 0.79 | KARS1 (0.60) | KARS1 | |
| SCHEMBL901769 | 0.78 | KARS1 (0.60) | KARS1SIRT2JAK2JAK1TYK2 | |
| SCHEMBL1704307 | 0.75 | KARS1 (0.49) | KARS1SIRT2ABL1 | |
| SCHEMBL1704666 | 0.74 | KARS1 (0.51) | KARS1 | |
| SCHEMBL1705115 | 0.74 | KARS1 (0.55) | KARS1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |