Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901565 | 1.00 | KARS1 (0.42) | KARS1CDK9GSK3BDYRK1APOLB | |
| SCHEMBL10269155 | 0.89 | WNT3A (0.43) | KARS1CDK9 | |
| SCHEMBL901761 | 0.86 | KARS1 (0.54) | KARS1CDK9GSK3BDYRK1ANAMPT | |
| SCHEMBL901842 | 0.81 | KARS1 (0.54) | KARS1DYRK1APOLB | |
| SCHEMBL901840 | 0.81 | KARS1 (0.54) | KARS1DYRK1APOLB | |
| SCHEMBL901948 | 0.79 | KARS1 (0.46) | KARS1CDK9NAMPT | |
| SCHEMBL901370 | 0.77 | KARS1 (0.45) | KARS1KMT2A | |
| SCHEMBL901369 | 0.77 | KARS1 (0.45) | KARS1KMT2A | |
| SCHEMBL1704842 | 0.76 | KARS1 (0.52) | KARS1CDK9NAMPT | |
| SCHEMBL901813 | 0.75 | ALDH1A1 (0.40) | KARS1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |