Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704430 | 0.88 | KARS1 (0.49) | KARS1CDK9 | |
| SCHEMBL901564 | 0.86 | KARS1 (0.42) | KARS1CDK9GSK3BDYRK1ANAMPT | |
| SCHEMBL901565 | 0.86 | KARS1 (0.42) | KARS1CDK9GSK3BDYRK1ANAMPT | |
| SCHEMBL901948 | 0.82 | KARS1 (0.46) | KARS1CDK9NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL901752 | 0.80 | KARS1 (0.73) | KARS1DYRK1A | |
| SCHEMBL1704842 | 0.78 | KARS1 (0.52) | KARS1CDK9NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL901769 | 0.77 | KARS1 (0.60) | KARS1NAMPTALDH1A1SMN1; SMN2 | |
| SCHEMBL10269155 | 0.76 | WNT3A (0.43) | KARS1CDK9 | |
| SCHEMBL901738 | 0.75 | KARS1 (0.58) | KARS1 | |
| SCHEMBL902044 | 0.73 | KARS1 (0.51) | KARS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |