Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.55 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9015966 | 0.84 | CPT1B (0.58) | ALOX5KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL9016004 | 0.83 | ALOX5 (0.54) | SMN1; SMN2ALOX5SLC29A1MEN1ALDH1A1 | |
| SCHEMBL9015965 | 0.80 | MEN1 (0.57) | ALOX5KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL11400309 | 0.78 | SMN1; SMN2 (0.78) | SMN1; SMN2TDP1SLC29A1KDM4EMEN1 | |
| Fumaric Acid SCHEMBL9296210 | 0.77 | MEN1 (0.54) | ALOX5KDM4EMEN1ALDH1A1KMT2A | |
| Fumaric Acid SCHEMBL9296208 | 0.77 | MEN1 (0.54) | ALOX5KDM4EMEN1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL10334149 | 0.74 | KDM4E (0.75) | SMN1; SMN2TDP1KDM4EMEN1ALDH1A1 | |
| SCHEMBL25834338 | 0.73 | KDM4E (0.69) | SMN1; SMN2TDP1KDM4EMEN1ALDH1A1 | |
| SCHEMBL9622306 | 0.72 | ALOX5 (0.47) | ALOX5KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL9832407 | 0.70 | KDM4E (0.81) | SMN1; SMN2TDP1KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533579-B1 | Trimetazidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-12-04 | — | — | EP | disclosed |
| US-5283246-A | Trimetazidine compounds | ADIR ET COMPAGNIE (FR) | 1994-02-01 | — | — | US | disclosed |
| EP-0533579-A1 | Trimetazidine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-03-24 | — | — | EP | disclosed |