Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | GSK3A | P49840 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18836217 | 0.76 | GSK3A (0.44) | SMN1; SMN2GSK3BGSK3AALDH1A1KDM4E | |
| SCHEMBL9786535 | 0.76 | ALDH1A1 (0.56) | SMN1; SMN2POLBRECQLALDH1A1KDM4E | |
| SCHEMBL1974808 | 0.74 | GAA (0.49) | SMN1; SMN2POLBRECQLALDH1A1KDM4E | |
| SCHEMBL4898108 | 0.73 | NOTUM (0.62) | ALDH1A1NOTUM | |
| SCHEMBL9786552 | 0.71 | PTGS2 (0.56) | TSHR | |
| SCHEMBL23371755 | 0.70 | BRPF1 (0.38) | POLBRECQLALDH1A1KDM4ECYP1A2 | |
| SCHEMBL1974506 | 0.70 | MEN1 (0.57) | SMN1; SMN2RECQLGSK3BALDH1A1KDM4E | |
| SCHEMBL13889904 | 0.69 | NOTUM (0.55) | SMN1; SMN2ALDH1A1KDM4ECYP1A2HPGD | |
| SCHEMBL3968827 | 0.68 | GSK3A (0.48) | SMN1; SMN2POLBRECQLGSK3BGSK3A | |
| SCHEMBL11456949 | 0.68 | MEN1 (0.52) | SMN1; SMN2POLBALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749425-A1 | NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME | SAMJIN PHARM. CO., LTD. (KR) | 1996-12-27 | — | — | EP | disclosed |