Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 15/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | MYC | P01106 | 3/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11454219 | 0.88 | NOTUM (0.63) | NOTUMALDH1A1MYCNR4A1 | |
| SCHEMBL3673624 | 0.86 | ALDH1A1 (0.48) | NOTUMALDH1A1MYCNR4A1 | |
| SCHEMBL11456565 | 0.85 | NOTUM (0.65) | NOTUMALDH1A1MYCNR4A1 | |
| SCHEMBL11456949 | 0.83 | MEN1 (0.52) | NOTUMALDH1A1MYCPLK1 | |
| SCHEMBL11458707 | 0.80 | ALDH1A1 (0.48) | NOTUMALDH1A1 | |
| SCHEMBL11455602 | 0.79 | NOTUM (0.73) | NOTUMALDH1A1 | |
| SCHEMBL11457533 | 0.78 | NOTUM (0.69) | NOTUMALDH1A1MYCNR4A1 | |
| SCHEMBL11463934 | 0.77 | MYC (0.56) | NOTUMALDH1A1MYCNR4A1 | |
| SCHEMBL3132883 | 0.76 | NOTUM (1.00) | NOTUMALDH1A1 | |
| SCHEMBL680769 | 0.75 | ALDH1A1 (0.57) | NOTUMALDH1A1MYCNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3096758-A1 | SUBSTITUTED N-ARYL PYRIDINONES | Auspex Pharmaceuticals, Inc. (US) | 2016-11-30 | — | — | EP | disclosed |
| US-9504677-B2 | Substituted N-aryl pyridinones | AUSPEX PHARMACEUTICALS, INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-20160331734-A1 | SUBSTITUTED N-ARYL PYRIDINONES | AUSPEX PHARMACEUTICALS, INC. | 2016-11-17 | — | — | US | disclosed |
| US-20150250777-A1 | SUBSTITUTED N-ARYL PYRIDINONES | PURETECH LYT 100, INC. | 2015-09-10 | — | — | US | disclosed |
| WO-2015112701-A1 | SUBSTITUTED N-ARYL PYRIDINONES | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-07-30 | — | — | WO | disclosed |
| US-9062001-B2 | Substituted N-aryl pyridinones | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20150126562-A1 | SUBSTITUTED N-ARYL PYRIDONES | AUSPEX PHARMACEUTICALS, INC. | 2015-05-07 | — | — | US | disclosed |
| US-9018232-B2 | Substituted N-aryl pyridinones | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-04-28 | — | — | US | disclosed |
| US-8969575-B2 | Substituted N-Aryl pyridinones | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-8969576-B2 | Substituted N-aryl pyridinones | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-20140348928-A1 | SUBSTITUTED N-ARYL PYRIDINONES | PURETECH LYT 100, INC. | 2014-11-27 | — | — | US | disclosed |
| US-20140235677-A1 | SUBSTITUTED N-ARYL PYRIDINONES | AUSPEX PHARMACEUTICALS, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140107040-A1 | SUBSTITUTED N-ARYL PYRIDINONES | AUSPEX PHARMACEUTICALS, INC. (US) | 2014-04-17 | — | — | US | disclosed |
| US-8680123-B1 | Substituted N-aryl pyridinones | AUSPEX PHARMACEUTICALS, INC (US) | 2014-03-25 | — | — | US | disclosed |
| US-20130345264-A1 | SUBSTITUTED N-ARYL PYRIDONES | AUSPEX PHARMACEUTICALS | 2013-12-26 | — | — | US | disclosed |
| US-8383823-B2 | Substituted N-aryl pyridinones | AUSPEX PHARMACEUTICALS (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2170828-B1 | SUBSTITUTED N-ARYL PYRIDINONES AS FIBROTIC INHIBITORS | AUSPEX PHARMACEUTICALS INC (US) | 2012-11-21 | — | — | EP | disclosed |
| US-20080319026-A1 | SUBSTITUTED N-ARYL PYRIDINONES | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107040-A1 | SUBSTITUTED N-ARYL PYRIDINONES | COL1A1, COL2A1, COLGALT1 | NOTUM 4252/4885ALDH1A1 293/4885MYC 3612/4885 |
| US-20140348928-A1 | SUBSTITUTED N-ARYL PYRIDINONES | COL1A1, COL2A1, COLGALT1 | NOTUM 4252/4885ALDH1A1 293/4885MYC 3612/4885 |
| US-20140235677-A1 | SUBSTITUTED N-ARYL PYRIDINONES | COL1A1, COL2A1, COLGALT1 | NOTUM 4252/4885ALDH1A1 293/4885MYC 3612/4885 |
| US-20150126562-A1 | SUBSTITUTED N-ARYL PYRIDONES | PIR, PDXK, PDGFRB | NOTUM 4274/4885ALDH1A1 108/4885MYC 1432/4885 |
| US-20130345264-A1 | SUBSTITUTED N-ARYL PYRIDONES | PIR, PDXK, PDGFRB | NOTUM 4274/4885ALDH1A1 108/4885MYC 1432/4885 |
| US-20080319026-A1 | SUBSTITUTED N-ARYL PYRIDINONES | COL1A1, COL2A1, COLGALT1 | NOTUM 4252/4885ALDH1A1 293/4885MYC 3612/4885 |
| US-20160331734-A1 | SUBSTITUTED N-ARYL PYRIDINONES | COL1A1, COL2A1, COLGALT1 | NOTUM 4256/4885ALDH1A1 329/4885MYC 3391/4885 |
| US-20150250777-A1 | SUBSTITUTED N-ARYL PYRIDINONES | COL1A1, COL2A1, COLGALT1 | NOTUM 4252/4885ALDH1A1 293/4885MYC 3612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.