Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP1 | P63208 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704340 | 0.89 | KARS1 (0.64) | KARS1GPR119CKS1BSKP1SKP2 | |
| SCHEMBL901876 | 0.86 | KARS1 (0.71) | KARS1DHFR | |
| SCHEMBL902237 | 0.85 | KARS1 (0.67) | KARS1JAK2JAK3ADORA2ASYK | |
| SCHEMBL1705310 | 0.84 | KARS1 (0.48) | KARS1JAK2JAK3GPR119PTK2 | |
| SCHEMBL1704583 | 0.82 | ADORA2A (0.48) | KARS1JAK2JAK3ADORA2AKIT | |
| SCHEMBL1705279 | 0.82 | GRM1 (0.47) | KARS1 | |
| SCHEMBL1704341 | 0.80 | KARS1 (0.55) | KARS1KITGPR119CKS1BSKP1 | |
| SCHEMBL1704429 | 0.79 | KARS1 (0.46) | KARS1JAK2ADORA2AKITGPR119 | |
| SCHEMBL901632 | 0.78 | KARS1 (1.00) | KARS1 | |
| SCHEMBL902759 | 0.78 | ADORA2A (0.60) | JAK2JAK3ADORA2AKITGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |