Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 15/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902044 | 0.84 | KARS1 (0.51) | KARS1 | |
| SCHEMBL1704222 | 0.82 | KARS1 (1.00) | KARS1 | |
| SCHEMBL1704429 | 0.79 | KARS1 (0.46) | KARS1 | |
| SCHEMBL901632 | 0.74 | KARS1 (1.00) | KARS1 | |
| SCHEMBL12469691 | 0.71 | KARS1 (0.72) | KARS1 | |
| SCHEMBL901823 | 0.70 | KARS1 (0.70) | KARS1 | |
| SCHEMBL1705644 | 0.69 | PIM1 (0.41) | KARS1 | |
| SCHEMBL901813 | 0.69 | ALDH1A1 (0.40) | KARS1 | |
| SCHEMBL902170 | 0.69 | KARS1 (0.77) | KARS1 | |
| SCHEMBL1704397 | 0.69 | KARS1 (0.77) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |