SCHEMBL9017343

SCHEMBL9017343

N#Cc1c(Br)c(C(F)(F)F)n(COC(=O)CNC(=O)c2ccc(Cl)cc2)c1-c1ccc(Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.44
MEN1 O00255 3/20 0.44
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 5/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
GAA P10253 1/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 3/20 0.37
TP53 P04637 2/20 0.37
POLB P06746 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GLA P06280 1/20 0.36
PKM P14618 1/20 0.36
MMP1 P03956 1/20 0.36
AR P10275 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
SLC6A9 P48067 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9017310 0.91 KMT2A (0.47) KMT2AMEN1MAPTSMN1; SMN2RAB9A
SCHEMBL9017287 0.89 POLB (0.37) KMT2AMEN1MAPTSMN1; SMN2ALDH1A1
SCHEMBL9017309 0.86 KMT2A (0.49) KMT2AMEN1MAPTSMN1; SMN2RAB9A
SCHEMBL9035868 0.84 ALDH1A1 (0.38) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL7503376 0.82 DRD2 (0.40) KMT2AMEN1MAPTGAAALDH1A1
SCHEMBL9036751 0.81 KDM4E (0.39) KMT2AMEN1MAPTALDH1A1HPGD
SCHEMBL9017316 0.80 RXFP1 (0.37) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL8994464 0.80 L3MBTL1 (0.34) KMT2AMEN1MAPTGAAALDH1A1
SCHEMBL8994468 0.79 RXFP1 (0.35) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL8994395 0.78 ALDH1A1 (0.33) KMT2AMEN1MAPTSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0594942-B1 N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID CO (US) 1996-09-04 EP claimed
EP-0594942-A1 N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID COMPANY (US) 1994-05-04 EP claimed
US-5286743-A N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-15 US claimed