SCHEMBL9017309

SCHEMBL9017309

N#Cc1c(Cl)c(C(F)(F)F)n(COC(=O)CNC(=O)c2ccccc2)c1-c1ccc(Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.49
MEN1 O00255 4/20 0.49
MAPT P10636 2/20 0.49
SMN1; SMN2 Q16637 4/20 0.41
BRCA1 P38398 1/20 0.39
GAA P10253 1/20 0.39
ALDH1A1 P00352 2/20 0.38
HPGD P15428 2/20 0.38
TP53 P04637 1/20 0.38
ADORA2A P29274 1/20 0.38
ADORA1 P30542 1/20 0.38
RAB9A P51151 3/20 0.38
KDM4E B2RXH2 1/20 0.38
GLA P06280 1/20 0.38
POLB P06746 1/20 0.38
PKM P14618 1/20 0.38
SLC6A9 P48067 2/20 0.38
SLC6A5 Q9Y345 2/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9017310 0.95 KMT2A (0.47) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL9017316 0.87 RXFP1 (0.37) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL9017343 0.86 KMT2A (0.44) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL9017293 0.85 MAPT (0.38) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL7503376 0.77 DRD2 (0.40) KMT2AMEN1MAPTGAAALDH1A1
SCHEMBL8994390 0.77 L3MBTL1 (0.35) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL9017287 0.76 POLB (0.37) KMT2AMEN1MAPTSMN1; SMN2ALDH1A1
SCHEMBL8994386 0.76 PAX8 (0.35) KMT2AMEN1MAPTSMN1; SMN2ALDH1A1
SCHEMBL5815133 0.75 KDM4E (0.36) KMT2AMEN1MAPTGAAALDH1A1
SCHEMBL9036751 0.74 KDM4E (0.39) KMT2AMEN1MAPTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0594942-B1 N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID CO (US) 1996-09-04 EP claimed
EP-0594942-A1 N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID COMPANY (US) 1994-05-04 EP claimed
US-5286743-A N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-15 US claimed