SCHEMBL9017310

SCHEMBL9017310

N#Cc1c(Cl)c(C(F)(F)F)n(COC(=O)CNC(=O)c2ccc(Cl)cc2)c1-c1ccc(Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.47
MEN1 O00255 3/20 0.47
MAPT P10636 2/20 0.47
SMN1; SMN2 Q16637 5/20 0.39
RAB9A P51151 3/20 0.39
NPC1 O15118 1/20 0.39
GAA P10253 1/20 0.39
ALDH1A1 P00352 2/20 0.38
HPGD P15428 3/20 0.37
POLB P06746 2/20 0.37
KDM4E B2RXH2 1/20 0.37
GLA P06280 1/20 0.37
PKM P14618 1/20 0.37
TP53 P04637 2/20 0.37
AR P10275 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
ADORA2A P29274 1/20 0.36
ADORA1 P30542 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9017309 0.95 KMT2A (0.49) KMT2AMEN1MAPTSMN1; SMN2RAB9A
SCHEMBL9017343 0.91 KMT2A (0.44) KMT2AMEN1MAPTSMN1; SMN2RAB9A
SCHEMBL9017316 0.89 RXFP1 (0.37) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL9017293 0.82 MAPT (0.38) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL9017287 0.80 POLB (0.37) KMT2AMEN1MAPTSMN1; SMN2ALDH1A1
SCHEMBL8994390 0.79 L3MBTL1 (0.35) KMT2AMEN1MAPTSMN1; SMN2GAA
SCHEMBL8994386 0.78 PAX8 (0.35) KMT2AMEN1MAPTSMN1; SMN2RAB9A
SCHEMBL5815133 0.77 KDM4E (0.36) KMT2AMEN1MAPTRAB9ANPC1
SCHEMBL5812558 0.75 RXFP1 (0.36) KMT2AMEN1MAPTGAAALDH1A1
SCHEMBL7494704 0.74 KDM4E (0.39) KMT2AMEN1MAPTGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0594942-B1 N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID CO (US) 1996-09-04 EP claimed
EP-0594942-A1 N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID COMPANY (US) 1994-05-04 EP claimed
US-5286743-A N-aminoalkylcarbonyloxyalkylpyrrole insecticidal acaricidal and molluscicidal agents AMERICAN CYANAMID COMPANY (US) 1994-02-15 US claimed
JP-6220012-A None JP disclosed
JP-H06220012-A N-AMINOALKYLCARBONYLOXYALKYLPYRROLE INSECTICIDAL, ACARICIDAL AND MOLLUSCICIDAL AGENTS AMERICAN CYANAMID CO 1994-08-09 JP disclosed