Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017842 | 1.00 | HSP90AA1 (0.42) | HSP90AA1BCHEACHEKMT2AALDH1A1 | |
| SCHEMBL9017886 | 0.84 | KDM4E (0.36) | BCHEACHEKMT2AALDH1A1KDM4E | |
| SCHEMBL9017883 | 0.84 | KDM4E (0.36) | BCHEACHEKMT2AALDH1A1KDM4E | |
| SCHEMBL9017908 | 0.82 | KDM4E (0.39) | BCHEKMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL9017903 | 0.82 | KDM4E (0.39) | BCHEKMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL9017843 | 0.81 | RAB9A (0.38) | BCHEALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL9017846 | 0.81 | RAB9A (0.38) | BCHEALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL9680966 | 0.80 | SMN1; SMN2 (0.42) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL9680971 | 0.80 | SMN1; SMN2 (0.42) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL9017866 | 0.77 | MEN1 (0.41) | KMT2AALDH1A1KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477903-B1 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0477903-A2 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-01 | — | — | EP | disclosed |