Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018239 | 0.99 | ALDH1A1 (0.40) | ALDH1A1MAPTKDM4ECXCR1CXCR2 | |
| SCHEMBL9018020 | 0.95 | HPGD (0.43) | ALDH1A1MAPTKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9018483 | 0.92 | GABRA5 (0.43) | ALDH1A1MAPTKDM4ECXCR1CXCR2 | |
| SCHEMBL9018502 | 0.91 | GABRA5 (0.43) | ALDH1A1MAPTKDM4ECXCR1CXCR2 | |
| SCHEMBL9018131 | 0.90 | HPGD (0.41) | ALDH1A1MAPTKDM4ECXCR1CXCR2 | |
| SCHEMBL9018501 | 0.90 | CXCR1 (0.42) | MAPTCXCR1CXCR2SMN1; SMN2LMNA | |
| SCHEMBL9018430 | 0.89 | ACACB (0.40) | ALDH1A1MAPTKDM4ECXCR1CXCR2 | |
| SCHEMBL9018187 | 0.88 | CA2 (0.45) | MAPTKDM4ECXCR1CXCR2HPGD | |
| SCHEMBL9018268 | 0.88 | RAB9A (0.46) | ALDH1A1HPGDSMN1; SMN2PDE4APDE4B | |
| SCHEMBL9018120 | 0.87 | CA2 (0.45) | MAPTKDM4ECXCR1CXCR2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |