Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018360 | 0.93 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2HPGDRECQL | |
| SCHEMBL9018118 | 0.92 | RAB9A (0.44) | RAB9ASMN1; SMN2HPGDKMT2ACASP3 | |
| SCHEMBL9018154 | 0.92 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2HPGDRECQL | |
| SCHEMBL9018341 | 0.92 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2HPGDRECQL | |
| SCHEMBL9018185 | 0.91 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2HPGDRECQL | |
| SCHEMBL9018269 | 0.90 | GABRA5 (0.44) | RAB9ASMN1; SMN2HPGDPOLBKMT2A | |
| SCHEMBL9018282 | 0.89 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2KMT2AP4HTM | |
| SCHEMBL7870551 | 0.88 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2HPGDPOLB | |
| SCHEMBL9018085 | 0.88 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2HPGDPOLB | |
| SCHEMBL9018327 | 0.87 | HPGD (0.44) | RAB9ANPC1SMN1; SMN2HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |