Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018312 | 0.93 | EPHX2 (0.47) | EPHX2ALDH1A1PKMOPRM1OPRD1 | |
| SCHEMBL9018486 | 0.92 | LMNA (0.42) | EPHX2ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL9018191 | 0.90 | EPHX2 (0.41) | EPHX2ALDH1A1PKMCA1CA2 | |
| SCHEMBL9018252 | 0.90 | MEN1 (0.39) | ALDH1A1LMNACYP3A4HTR1AMAPT | |
| SCHEMBL9018435 | 0.87 | ALDH1A1 (0.39) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL9018301 | 0.87 | CA1 (0.41) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL9018198 | 0.87 | OPRM1 (0.40) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL9018345 | 0.87 | OPRM1 (0.40) | EPHX2ALDH1A1CA1CA2CA7 | |
| SCHEMBL7862673 | 0.85 | EPHX2 (0.44) | EPHX2ALDH1A1PKMLMNACYP3A4 | |
| SCHEMBL7867707 | 0.85 | EPHX2 (0.46) | EPHX2ALDH1A1PKMLMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |