Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018392 | 0.96 | CA2 (0.48) | EGLN1CYP2C9CYP2C19CA2LMNA | |
| SCHEMBL9018436 | 0.92 | CA2 (0.46) | CYP2C9CA2ALDH1A1LMNAALB | |
| SCHEMBL9018217 | 0.92 | ALDH1A1 (0.46) | EGLN1ALDH1A1TSHREGFRP4HTM | |
| SCHEMBL9018148 | 0.92 | CA2 (0.42) | EGLN1CYP2C9CA2ALDH1A1LMNA | |
| SCHEMBL9018422 | 0.91 | CA2 (0.41) | EGLN1CYP2C9CA2ALDH1A1LMNA | |
| SCHEMBL9018479 | 0.90 | EGFR (0.43) | EGFRP4HTMOPRK1EPHX2 | |
| SCHEMBL9018325 | 0.90 | SMN1; SMN2 (0.44) | EGLN1CYP2C9CYP2C19LMNAP4HTM | |
| SCHEMBL9018202 | 0.90 | P4HTM (0.43) | ALDH1A1EGFRP4HTMEPHX2KMT2A | |
| SCHEMBL9018141 | 0.89 | NPC1 (0.48) | P4HTMOPRK1NPC1RAB9AEPHX2 | |
| SCHEMBL9018337 | 0.89 | ALDH1A1 (0.45) | CYP2C9CA2ALDH1A1LMNAALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |