Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902605 | 0.80 | KARS1 (0.56) | KARS1NPC1RAB9A | |
| SCHEMBL12469132 | 0.79 | KARS1 (0.72) | KARS1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL901872 | 0.77 | KARS1 (0.52) | KARS1NPC1RAB9ABRAF | |
| SCHEMBL901917 | 0.76 | KARS1 (0.53) | KARS1 | |
| SCHEMBL1704829 | 0.75 | KARS1 (0.43) | KARS1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL902923 | 0.74 | NPC1 (0.36) | KARS1NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL902774 | 0.73 | ALDH1A1 (0.37) | KARS1NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL901844 | 0.73 | KARS1 (0.52) | KARS1MAPTSLC5A1HPGD | |
| SCHEMBL901976 | 0.73 | ALDH1A1 (0.46) | NPC1ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL901874 | 0.73 | ASIC3 (0.47) | KDM4ELMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |