Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.39 |
| ▸ | CCR2 | P41597 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018268 | 0.89 | RAB9A (0.46) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL9140113 | 0.89 | SMN1; SMN2 (0.45) | SMN1; SMN2CA1CA2CA9ALDH1A1 | |
| SCHEMBL9018540 | 0.89 | RAB9A (0.47) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL9017981 | 0.88 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL9018349 | 0.88 | ALDH1A1 (0.49) | SMN1; SMN2CA1CA2CA9ALDH1A1 | |
| SCHEMBL9018281 | 0.85 | ALDH1A1 (0.47) | SMN1; SMN2CA1CA2CA9ALDH1A1 | |
| SCHEMBL7862784 | 0.83 | HPGD (0.46) | SMN1; SMN2CA1CA2CA9ALDH1A1 | |
| SCHEMBL7867706 | 0.83 | HPGD (0.48) | SMN1; SMN2CA1CA2CA9ALDH1A1 | |
| SCHEMBL7874495 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2CA1CA2CA9ALDH1A1 | |
| SCHEMBL9018303 | 0.80 | MCL1 (0.51) | BCL2L1MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |