Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.39 |
| ▸ | CKS1B | P61024 | 2/20 | 0.39 |
| ▸ | SKP1 | P63208 | 2/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | BUB1 | O43683 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901704 | 0.88 | CKS1B (0.48) | KARS1CKS1BSKP1SKP2GBA1 | |
| SCHEMBL902855 | 0.84 | KARS1 (0.40) | KARS1CKS1BSKP1SKP2GBA1 | |
| SCHEMBL1704584 | 0.84 | PARP1 (0.45) | KARS1GPR119BUB1 | |
| SCHEMBL901300 | 0.81 | KARS1 (0.49) | KARS1SYK | |
| SCHEMBL901702 | 0.79 | KARS1 (0.51) | KARS1 | |
| SCHEMBL902751 | 0.78 | CKS1B (0.47) | KARS1CKS1BSKP1SKP2GBA1 | |
| SCHEMBL1705250 | 0.77 | ACHE (0.47) | CKS1BSKP1SKP2GBA1GPR119 | |
| SCHEMBL902803 | 0.77 | PDE10A (0.45) | CCNT1CDK9 | |
| SCHEMBL901409 | 0.76 | KARS1 (0.41) | KARS1 | |
| SCHEMBL1704806 | 0.76 | CKS1B (0.47) | CKS1BSKP1SKP2GBA1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |