SCHEMBL9019103

SCHEMBL9019103

N#CCOn1c(Br)c(Br)c(C#N)c1-c1ccc(Cl)cc1

nearest known ligand 0.33

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.33
MAPT P10636 2/20 0.33
KMT2A Q03164 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
GRIA2 P42262 1/20 0.33
GRIA4 P48058 1/20 0.33
NTRK1 P04629 1/20 0.32
PIM1 P11309 1/20 0.32
ACVR1 Q04771 1/20 0.32
HTT P42858 1/20 0.32
USP2 O75604 1/20 0.32
THRB P10828 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 2/20 0.32
NPSR1 Q6W5P4 1/20 0.32
HPGD P15428 2/20 0.31
CNR1 P21554 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9019106 0.82 MAOB (0.41) MEN1MAPTKMT2ASMN1; SMN2GRIA2
SCHEMBL9019093 0.81 L3MBTL1 (0.36) MEN1MAPTKMT2ASMN1; SMN2GRIA2
SCHEMBL9019066 0.74 MAOB (0.33)
SCHEMBL9019044 0.74 MAOA (0.38) MEN1MAPTKMT2AGRIA2GRIA4
SCHEMBL9702818 0.74 GRIA4 (0.37) MEN1MAPTKMT2AGRIA2GRIA4
SCHEMBL9019009 0.71 MAOB (0.45) MEN1MAPTKMT2AGRIA2GRIA4
SCHEMBL9519227 0.68 GRIA2 (0.42) MEN1MAPTKMT2AGRIA2GRIA4
SCHEMBL9019084 0.68 MAOB (0.44) MEN1MAPTKMT2AGRIA2GRIA4
SCHEMBL9019071 0.68 MAOB (0.39) MEN1MAPTKMT2ASMN1; SMN2KDM4E
SCHEMBL9019080 0.67 HPGD (0.34) MEN1MAPTKMT2AUSP2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0434940-B1 N-oxygenated arylpyrrole, insecticidal, acaricidal and nematicidal agents AMERICAN CYANAMID CO (US) 1996-05-29 EP claimed
US-5102904-A N-OXYGENATED ARYLPYRROLE INSECTICIDAL, ACARICIDAL AND NEMATICIDAL AGENTS AND USE THEREAS AMERICAN CYANAMID COMPANY (US) 1992-04-07 US claimed
EP-0434940-A2 N-oxygenated arylpyrrole, insecticidal, acaricidal and nematicidal agents AMERICAN CYANAMID COMPANY (US) 1991-07-03 EP claimed