Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.46 |
| ▸ | SKP1 | P63208 | 2/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.44 |
| ▸ | PGK1 | P00558 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901952 | 0.87 | LMNA (0.45) | — | |
| SCHEMBL17310093 | 0.82 | SUV39H2 (0.49) | CKS1BSKP1SKP2SUV39H2PGK1 | |
| SCHEMBL1704536 | 0.82 | LMNA (0.45) | CKS1BSKP1SKP2LRRK2SUV39H2 | |
| SCHEMBL1704732 | 0.82 | KARS1 (0.52) | CKS1BSKP1SKP2LRRK2TBK1 | |
| SCHEMBL902930 | 0.81 | FLT3 (0.46) | CKS1BSKP1SKP2LRRK2TBK1 | |
| SCHEMBL30546118 | 0.81 | HRH3 (0.57) | CKS1BSKP1SKP2LRRK2GPR119 | |
| SCHEMBL5682996 | 0.81 | HRH3 (0.57) | CKS1BSKP1SKP2LRRK2GPR119 | |
| SCHEMBL1704646 | 0.80 | GPR119 (0.42) | CKS1BSKP1SKP2LRRK2SUV39H2 | |
| SCHEMBL29157436 | 0.79 | LRRK2 (0.54) | CKS1BSKP1SKP2LRRK2TBK1 | |
| SCHEMBL901912 | 0.78 | CKS1B (0.52) | CKS1BSKP1SKP2LRRK2PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |