SCHEMBL9019128

SCHEMBL9019128

COn1cc(C#N)c(C#N)c1-c1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.42
ALDH1A1 P00352 7/20 0.42
GAA P10253 2/20 0.42
MAOA P21397 3/20 0.40
LMNA P02545 3/20 0.40
HPGD P15428 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
SQOR Q9Y6N5 1/20 0.38
NPSR1 Q6W5P4 2/20 0.35
USP2 O75604 1/20 0.35
THRB P10828 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
PPARG P37231 1/20 0.35
STAT3 P40763 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
NR2E3 Q9Y5X4 1/20 0.35
NCOR2 Q9Y618 1/20 0.35
HTT P42858 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9019078 0.80 VCAM1 (0.41) KDM4EALDH1A1GAALMNAHPGD
SCHEMBL9019083 0.79 KDM4E (0.43) KDM4EALDH1A1GAAMAOALMNA
SCHEMBL9019130 0.72 USP2 (0.38) KDM4EALDH1A1GAAMAOALMNA
SCHEMBL9019009 0.71 MAOB (0.45) KDM4EALDH1A1GAAMAOALMNA
SCHEMBL9019084 0.70 MAOB (0.44) KDM4EALDH1A1MAOALMNAHPGD
SCHEMBL9019106 0.70 MAOB (0.41) KDM4EALDH1A1MAOALMNAHPGD
SCHEMBL10590178 0.66 USP2 (0.44) KDM4EALDH1A1GAAMAOALMNA
SCHEMBL27286713 0.65 KDM4E (0.41) KDM4EALDH1A1GAAMAOALMNA
SCHEMBL9019069 0.65 ALDH1A1 (0.46) KDM4EALDH1A1GAAMAOALMNA
SCHEMBL7543853 0.64 KDM4E (0.44) KDM4EALDH1A1GAAMAOALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0434940-B1 N-oxygenated arylpyrrole, insecticidal, acaricidal and nematicidal agents AMERICAN CYANAMID CO (US) 1996-05-29 EP disclosed
US-5399716-A N-oxygenated arylpyrrole insecticidal, acaricidal and nematicidal agents AMERICAN CYANAMID COMPANY (US) 1995-03-21 US disclosed
US-5347016-A N-oxygenated arylpyrrole intermediates for insecticidal, acaricidal and nematicidal agents AMERICAN CYANAMID COMPANY (US) 1994-09-13 US disclosed
US-5232979-A Insecticides, miticides, nematocides AMERICAN CYANAMID COMPANY (US) 1993-08-03 US disclosed
US-5102904-A N-OXYGENATED ARYLPYRROLE INSECTICIDAL, ACARICIDAL AND NEMATICIDAL AGENTS AND USE THEREAS AMERICAN CYANAMID COMPANY (US) 1992-04-07 US disclosed
EP-0434940-A2 N-oxygenated arylpyrrole, insecticidal, acaricidal and nematicidal agents AMERICAN CYANAMID COMPANY (US) 1991-07-03 EP disclosed