Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.60 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.60 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.59 |
| ▸ | POLH | Q9Y253 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | APEX1 | P27695 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019366 | 0.76 | CYP19A1 (0.56) | MAOAABCB1CYP1B1CYP1A1CYP1A2 | |
| Kaempferide SCHEMBL426774 | 0.76 | CYP1A2 (1.00) | MAOAABCB1CYP1B1CYP1A1CYP1A2 | |
| Kaempferide SCHEMBL29371282 | 0.76 | CYP1A2 (1.00) | MAOAABCB1CYP1B1CYP1A1CYP1A2 | |
| Ermanin SCHEMBL2875089 | 0.75 | CYP3A4 (1.00) | MAOAABCB1CYP1B1CYP1A1CYP1A2 | |
| SCHEMBL6504199 | 0.74 | CYP1B1 (0.77) | MAOAABCB1CYP1B1CYP1A1CYP1A2 | |
| Nonacosane SCHEMBL28207166 | 0.74 | ABCB1 (0.83) | MAOAABCB1CYP1B1CYP1A1CYP1A2 | |
| SCHEMBL9733059 | 0.74 | ABCB1 (0.57) | MAOAABCB1CYP1B1CYP1A1CYP1A2 | |
| SCHEMBL9733091 | 0.72 | ABCB1 (0.53) | MAOAABCB1CYP1B1CYP1A1CYP1A2 | |
| SCHEMBL9019328 | 0.72 | ADORA3 (0.49) | CYP3A4KDM4EMEN1MAPTKMT2A | |
| SCHEMBL28315058 | 0.71 | CYP3A4 (0.74) | MAOAABCB1CYP1B1CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450588-B1 | Substituted 3-thia- or 3-oxa-alkyl flavones, process for their preparation, their application and drugs based on these compounds as well as intermediates | HOECHST AG (DE) | 1996-02-28 | — | — | EP | disclosed |
| EP-0450588-A1 | Substituted 3-thia- or 3-oxa-alkyl flavones, process for their preparation, their application and drugs based on these compounds as well as intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-09 | — | — | EP | disclosed |