Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.53 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | MGAM | O43451 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | SI | P14410 | 4/20 | 0.52 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019339 | 0.76 | MAOA (0.60) | CYP19A1CYP1A1CYP1A2ABCB1MAOA | |
| SCHEMBL6822937 | 0.72 | CYP19A1 (1.00) | CYP19A1MGAMGAASIMGAM2 | |
| SCHEMBL6822936 | 0.72 | CYP19A1 (1.00) | CYP19A1MGAMGAASIMGAM2 | |
| Kaempferide SCHEMBL29371282 | 0.71 | CYP1A2 (1.00) | CYP19A1CYP1A1CYP1A2ABCB1MAOA | |
| Kaempferide SCHEMBL426774 | 0.71 | CYP1A2 (1.00) | CYP19A1CYP1A1CYP1A2ABCB1MAOA | |
| SCHEMBL29580242 | 0.71 | CYP19A1 (0.69) | CYP19A1CYP1A1CYP1A2CYP1B1MGAM | |
| Ermanin SCHEMBL2875089 | 0.70 | CYP3A4 (1.00) | CYP1A1CYP1A2ABCB1MAOACYP1B1 | |
| SCHEMBL28037283 | 0.70 | CYP19A1 (0.69) | CYP19A1MAOAMGAMGAASI | |
| SCHEMBL6504199 | 0.69 | CYP1B1 (0.77) | CYP19A1CYP1A1CYP1A2ABCB1MAOA | |
| Rubraxanthone SCHEMBL8664946 | 0.69 | MGAM (0.79) | CYP19A1CYP3A4CYP2D6MGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450588-B1 | Substituted 3-thia- or 3-oxa-alkyl flavones, process for their preparation, their application and drugs based on these compounds as well as intermediates | HOECHST AG (DE) | 1996-02-28 | — | — | EP | disclosed |
| US-5173498-A | For treating arteriosclerosis or hypercholesterolemia | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-12-22 | — | — | US | disclosed |
| EP-0450588-A1 | Substituted 3-thia- or 3-oxa-alkyl flavones, process for their preparation, their application and drugs based on these compounds as well as intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-09 | — | — | EP | disclosed |