Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | NQO2 | P16083 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20464228 | 0.78 | KDM4E (0.45) | ADORA2AALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL21333989 | 0.77 | ALOX5 (0.47) | ADORA2BADORA2ANQO2PDE10AMAPT | |
| SCHEMBL31472682 | 0.77 | ALOX5 (0.47) | ADORA2BADORA2ANQO2PDE10AMAPT | |
| SCHEMBL23024888 | 0.73 | CYP11B1 (0.57) | ADORA2BADORA2ANQO2ALDH1A1MAPT | |
| SCHEMBL29516239 | 0.72 | CYP1A2 (0.44) | ADORA2AALDH1A1ADORA1MAPTL3MBTL1 | |
| SCHEMBL24287306 | 0.72 | CYP1A2 (0.44) | ADORA2AALDH1A1ADORA1MAPTL3MBTL1 | |
| SCHEMBL29893280 | 0.72 | KIF11 (0.43) | MAPK13MAPK12MAPK11MAPK14CYP3A4 | |
| SCHEMBL902808 | 0.72 | SYK (0.43) | ADORA2BADORA2ANQO2PDE10AMAPT | |
| SCHEMBL901573 | 0.70 | MAPK1 (0.42) | ALDH1A1MAPTL3MBTL1LMNAMAPK1 | |
| SCHEMBL29091622 | 0.70 | L3MBTL1 (0.43) | NQO2ALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |