Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901708 | 0.79 | KARS1 (0.66) | KARS1DYRK1A | |
| SCHEMBL901846 | 0.79 | KARS1 (0.46) | KARS1ADORA2APDE10A | |
| SCHEMBL902716 | 0.79 | KARS1 (0.46) | KARS1ADORA2APDE10A | |
| SCHEMBL901301 | 0.79 | KARS1 (0.46) | KARS1ADORA2APDE10A | |
| SCHEMBL901245 | 0.77 | KARS1 (0.52) | KARS1 | |
| SCHEMBL902695 | 0.76 | KARS1 (0.60) | SYKMAPTMAP4K4MINK1TNIK | |
| SCHEMBL901702 | 0.76 | KARS1 (0.51) | KARS1DYRK1A | |
| SCHEMBL901860 | 0.76 | KARS1 (0.46) | KARS1 | |
| SCHEMBL902032 | 0.75 | KARS1 (0.52) | KARS1 | |
| SCHEMBL901736 | 0.74 | KARS1 (0.51) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |