Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30176172 | 0.91 | UCHL1 (0.36) | NR1H2UCHL1HTRA1CHRM2CHRM1 | |
| SCHEMBL9020470 | 0.90 | UCHL1 (0.34) | NR1H2UCHL1HTRA1CHRM2CHRM1 | |
| SCHEMBL9754778 | 0.89 | MEN1 (0.30) | — | |
| SCHEMBL9400105 | 0.83 | NR1H2 (0.35) | NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL9399192 | 0.82 | NR1H2 (0.34) | NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL30176161 | 0.81 | HTRA1 (0.35) | NR1H2UCHL1HTRA1CHRM2CHRM1 | |
| SCHEMBL9020384 | 0.81 | CHRM2 (0.33) | NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL31040353 | 0.81 | NR1H2 (0.35) | NR1H2CHRM2CHRM1CHRM3 | |
| SCHEMBL9020656 | 0.81 | GPR119 (0.43) | — | |
| SCHEMBL9399808 | 0.81 | RIPK1 (0.35) | NR1H2CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449191-B1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | BANYU PHARMA CO LTD (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5438054-A | Antibacterial agent | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-08-01 | — | — | US | disclosed |
| US-5374720-A | A thienamycins bactericides has nontoxic, side effect reduction against the kidney and central nervous system | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-12-20 | — | — | US | disclosed |
| EP-0449191-A1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | Banyu Pharmaceutical Co., Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |