Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.62 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902559 | 0.92 | DGAT1 (0.61) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL902020 | 0.89 | DGAT1 (0.59) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL902764 | 0.83 | DGAT1 (0.42) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL902158 | 0.77 | DGAT1 (0.50) | DGAT1SOAT1KCNH2ADORA2APTGDR2 | |
| SCHEMBL10325681 | 0.77 | DGAT1 (0.62) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL10380812 | 0.77 | DGAT1 (0.61) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL901617 | 0.77 | DGAT1 (0.50) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL10146485 | 0.74 | DGAT1 (0.67) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL902608 | 0.72 | DGAT1 (0.45) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL902703 | 0.72 | DGAT1 (1.00) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |