Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 12/20 | 0.45 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10188922 | 0.76 | DGAT1 (0.41) | DGAT1SOAT1KCNH2ADORA2AFFAR4 | |
| SCHEMBL902786 | 0.75 | DGAT1 (0.40) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902149 | 0.72 | DGAT1 (0.62) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL902559 | 0.72 | DGAT1 (0.61) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL901617 | 0.71 | DGAT1 (0.50) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902148 | 0.71 | SOS1 (0.33) | DGAT1SOAT1KCNH2CYP2C9CYP3A4 | |
| SCHEMBL902020 | 0.70 | DGAT1 (0.59) | DGAT1SOAT1KCNH2ADORA2ACYP2C9 | |
| SCHEMBL10381238 | 0.69 | NPBWR1 (0.42) | DGAT1SOAT1KCNH2NPBWR1 | |
| SCHEMBL10189190 | 0.69 | DGAT1 (0.44) | DGAT1SOAT1KCNH2ADORA2AIDO1 | |
| SCHEMBL901631 | 0.68 | CDK9 (0.32) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |