Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8586185 | 0.80 | SIGMAR1 (0.56) | MMP2MMP3POLBCNR2CHRM2 | |
| SCHEMBL5685856 | 0.79 | SIGMAR1 (0.54) | MMP2MMP3POLBCHRM2CHRM1 | |
| SCHEMBL20848073 | 0.79 | SIGMAR1 (0.54) | MMP2MMP3POLBCHRM2CHRM1 | |
| SCHEMBL9275296 | 0.79 | SIGMAR1 (0.54) | MMP2MMP3POLBCHRM2CHRM1 | |
| SCHEMBL5321390 | 0.79 | SIGMAR1 (0.54) | MMP2MMP3POLBCHRM2CHRM1 | |
| SCHEMBL9023031 | 0.74 | NAAA (0.48) | POLBALDH1A1NAAASIGMAR1 | |
| Hydrochloric Acid SCHEMBL6261405 | 0.73 | NAAA (0.47) | POLBALDH1A1NAAASIGMAR1 | |
| SCHEMBL1132061 | 0.71 | TAAR1 (0.53) | POLBCNR2OPRK1ALDH1A1ASAH1 | |
| SCHEMBL598533 | 0.70 | RIPK1 (0.53) | POLBRIPK1SIGMAR1 | |
| SCHEMBL10126780 | 0.70 | ADRA1A (0.57) | POLBCHRM2ADRA2BADRA1AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471493-B1 | N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase | AMERICAN HOME PROD (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5399697-A | N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |
| US-5380853-A | Atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-01-10 | — | — | US | disclosed |
| US-5281714-A | Enzyme inhibitors or antioxidants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-01-25 | — | — | US | disclosed |
| US-5179216-A | Anticholesterol agents and atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-01-12 | — | — | US | disclosed |
| EP-0471493-A1 | N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-02-19 | — | — | EP | disclosed |