SCHEMBL9023294

SCHEMBL9023294

N#Cc1c(-c2ccc(C=O)cc2)n(O)c2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 4/20 0.41
MAOB P27338 3/20 0.41
CYP11B2 P19099 2/20 0.39
ALDH1A1 P00352 5/20 0.38
MAPK1 P28482 1/20 0.38
STAT3 P40763 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
KDM4E B2RXH2 3/20 0.38
EGFR P00533 2/20 0.36
SRC P12931 1/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
ATM Q13315 1/20 0.36
LMNA P02545 3/20 0.35
GAA P10253 2/20 0.34
MAPT P10636 2/20 0.34
CACNA1B Q00975 1/20 0.34
APBA1 Q02410 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
GLA P06280 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9022520 0.85 MAOA (0.40) MAOAMAOBCYP11B2ALDH1A1MAPK1
SCHEMBL9022513 0.85 MAOA (0.40) MAOAMAOBCYP11B2ALDH1A1MAPK1
SCHEMBL9378930 0.84 MAOA (0.39) MAOAMAOBCYP11B2ALDH1A1MAPK1
SCHEMBL9378933 0.84 MAOA (0.39) MAOAMAOBCYP11B2ALDH1A1MAPK1
SCHEMBL9022740 0.84 MAOA (0.51) MAOAMAOBCYP11B2ALDH1A1MAPK1
SCHEMBL9023051 0.81 PARP1 (0.42) MAOAMAOBCYP11B2ALDH1A1MAPK1
SCHEMBL9023167 0.80 PGR (0.45) MAOAMAOBCYP11B2ALDH1A1MAPK1
SCHEMBL9023203 0.78 MEN1 (0.47) CYP11B2ALDH1A1MAPK1KDM4EMEN1
SCHEMBL9023138 0.78 CYP11B2 (0.51) MAOAMAOBCYP11B2ALDH1A1MAPK1
SCHEMBL9381891 0.78 ALDH1A1 (0.38) MAOAMAOBCYP11B2ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0472231-B1 2-Substituted-1-hydroxyindoles EASTMAN KODAK CO (US) 1994-10-26 EP claimed
EP-0472231-A1 2-Substituted-1-hydroxyindoles EASTMAN KODAK COMPANY (US) 1992-02-26 EP claimed
EP-0470665-B1 1-Hydroxyindole fungicides EASTMAN KODAK CO (US) 1996-04-24 EP disclosed
EP-0472231-B1 2-Substituted-1-hydroxyindoles EASTMAN KODAK CO (US) 1994-10-26 EP disclosed
US-5183894-A Agricultural fungicides EASTMAN KODAK COMPANY (US) 1993-02-02 US disclosed
US-5118695-A 1-HYDROXYINDOLE FUNGICIDES EASTMAN KODAK COMPANY (US) 1992-06-02 US disclosed
EP-0472231-A1 2-Substituted-1-hydroxyindoles EASTMAN KODAK COMPANY (US) 1992-02-26 EP disclosed
EP-0470665-A1 1-Hydroxyindole fungicides EASTMAN KODAK COMPANY (US) 1992-02-12 EP disclosed