Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | METAP2 | P50579 | 2/20 | 0.58 |
| ▸ | METAP1 | P53582 | 2/20 | 0.58 |
| ▸ | CBFB | Q13951 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13286844 | 0.81 | NPC1 (0.57) | ADORA3METAP2METAP1CBFBALDH1A1 | |
| SCHEMBL903006 | 0.80 | METAP2 (0.61) | METAP2METAP1CBFBNPC1DGAT1 | |
| SCHEMBL902815 | 0.79 | CBFB (0.64) | CBFBDGAT1 | |
| SCHEMBL34849 | 0.78 | ADORA3 (0.47) | ADORA3METAP2METAP1CBFBALDH1A1 | |
| SCHEMBL902354 | 0.77 | CBFB (0.64) | CBFBNPC1P2RY6DGAT1BACE1 | |
| SCHEMBL4900779 | 0.77 | METAP2 (0.57) | ADORA3METAP2METAP1CBFBALDH1A1 | |
| SCHEMBL34855 | 0.77 | NPC1 (0.55) | ADORA3METAP2METAP1CBFBALDH1A1 | |
| SCHEMBL5952973 | 0.77 | METAP2 (0.57) | ADORA3METAP2METAP1CBFBALDH1A1 | |
| SCHEMBL29898236 | 0.72 | KDM4E (1.00) | ADORA3METAP2METAP1CBFBALDH1A1 | |
| SCHEMBL8337597 | 0.72 | KDM4E (1.00) | ADORA3METAP2METAP1CBFBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |